
趙凱,1973年12月,二級教授,臺州學院納米生物材料與免疫學創新團隊首席科學家、生命科學學院院長、生物與醫藥專業碩士學位培育點負責人、臺州市生物醫藥與高端劑型重點實驗室主任
學習經歷
2001/09 – 2004/07,東北農業大學,食品科學與技術學院,博士
1998/09 – 2001/07,東北農業大學,動物醫學院,碩士
1994/09 – 1998/07,黑龍江八一農墾大學,動物科技學院,學士
工作經歷
2021/04 – 至今,臺州學院,高等研究院/生命科學學院,教授
2021/04 – 至今,黑龍江大學,生命科學學院兼職教授
2016/12 – 2018/01,University of Florida,訪問學者
2009/09 – 2021/04,黑龍江大學,生命科學學院,教授
2006/09 – 2009/08,黑龍江大學,生命科學學院,副教授
2004/12 – 2007/02,中國農業科學院哈爾濱獸醫研究所,博士后
2004/07 – 2006/08,黑龍江大學,生命科學學院,講師
研究方向
腸道微生物菌群與腸道免疫、微生態制劑與替抗新產品、疫苗/藥物遞送系統、動物疫苗、藥物高端制劑、檢測新試劑
代表作
發表學術論文(部分):
(1)Yinzhuo Xie, Wei Xu, Zheng Jin,Kai Zhao*. Chondroitin sulfate functionalized palmitic acid and cysteine cografted-quaternized chitosan for CD44 and gut microbiota dual-targeted delivery of curcumin. Materials Today Bio. 2023,20: 100617.(SCI IF8.2)
(2)Yinzhuo Xie, Zheng Jin, Da Ma, Tan Hui Yin,Kai Zhao*. Palmitic acid- and cysteine-functionalized nanoparticles overcome mucus and epithelial barrier for oral delivery of drug. Bioengineering & Translational Medicine. 2023,e10510.(SCI IF7.4)
(3)Zhi Zhao, Yue Peng, Xueao Shi,Kai Zhao*. Chitosan derivative composite nanoparticles as adjuvants enhance the cellular immune responseviaactivation of the cGAS-STING pathway. International Journal of Pharmaceutics. 2023,636: 122847.(SCI IF5.8)
(4)Shangen Xu, Lu Yu, Qiaoyang Teng, Xuesong Li, Zheng Jin, Yang Qu, Jiawei Li, Qihong Zhang, Zejun Li *,Kai Zhao*.Enhance immune response to H9 AIV DNA vaccine based on polygene expression and DGL nanoparticle encapsulation.Poultry Science.2023,102: 102925.(SCI IF4.4)
(5)Shangen Xu, Hailing Lan, Qiaoyang Teng, Xuesong Li, Zheng Jin, Yang Qu, Jiawei Li,Qihong Zhang, Hong Kang, Tan Hui Yin, Zejun Li*,Kai Zhao*.An immune-enhanced multivalent DNA nanovaccine to prevent H7 and H9 avian influenza virus in mice.International Journal of Biological Macromolecules.2023, 251: 126286.(SCI IF8.2)
(6)Yiyu Wang, Xinyu Wang, Xingxun Liu, Chunqing Niu, Guiting Yu, Yuanjing Hou, Chao Hu,Kai Zhao*, Jian Shi*. Fabrication, characterization and potential application of biodegradable polydopamine-modified scaffolds based on natural macromolecules.International Journal of Biological Macromolecules.2023, .(SCI IF8.2)
(7)JialiLiu,SihanGuo,ZhengJin?,KaiZhao?.Adjuvanted quaternized chitosan composite aluminum nanoparticles-based vaccine formulation promotes immune responses in chickens. Vaccine. 2023, 41: 2982-2989.(SCI IF4.169)
(8)Guiting Yu, Chunqing Niu, Jiali Liu, Jue Wu, Zheng Jin*, Yiyu Wang*, Kai Zhao*.Preparation and properties of self-crosslinking hydrogels based on chitosan derivatives and oxidized sodium alginate.ACS Omega. ACS Omega.2023,8: 19752-19766.(SCI IF4.1)
(9)Jue Wu, Qian Chen, Wenfei Wang, Yuhong Lin, HongKang, Zheng Jin*,Kai Zhao*.Chitosanderivative-basedmicrospheresloaded withfibroblastgrowthfactor for thetreatment ofdiabetes.Polymers.2023, 15:3099.(SCI IF5.0)
(10)Chen Zhang,Zheng Jin*,Yuhong lin,Yiyu Wang,Kai Zhao*.Functionalized N-hydroxypropyl trimethylammonium chloride chitosan as an ICG/DOX co-delivery nanocarriers for targetedand chemo-photothermal combination therapy.Journal of Drug Delivery Science and Technology. 2023, 88: 104920.(SCI IF5.0)
(11)Zheng Jin, Gaowei Hu,Kai Zhao*. Mannose-anchored quaternized chitosan/thiolated carboxymethyl chitosan composite NPs as mucoadhesive carrier for drug delivery. Carbohydrate Polymers. 2022, 283: 119174.(SCI IF 11.2)
(12)Yuhong Lin, Beini Sun, Zheng Jin,Kai Zhao*.Enhanced immune responses to mucosa by functionalized chitosan-based composite nanoparticle as vaccine adjuvant for intranasal delivery.ACS Applied Materials & Interfaces. 2022,14:52691-52701.(SCI IF9.5)
(13)Yuan Gao, Xiaochen Gong, Shuang Yu, Zheng Jin, Qicheng Rua, Chunjing Zhang,Kai Zhao*.Immune enhancement ofN-2-Hydroxypropyl trimethyl ammonium chloride chitosan/carboxymethyl chitosan nanoparticles vaccine.International Journal of Biological Macromolecules. 2022, 220: 183-192.(SCI IF8.2)
(14)Zhi Zhao, Jinyu Han, Shangen Xu, Zheng Jin, Tan Hui Yin,Kai Zhao*.Amoxicillin encapsulated in theN-2-Hydroxypropyl trimethyl ammonium chloride chitosan andN,O-carboxymethyl chitosan nanoparticles: Preparation, characterization, and antibacterial activity.International Journal of Biological Macromolecules. 2022, 221: 613-622.(SCI IF8.2)
(15)Yinzhuo Xie, Xiaochen Gong, Zheng Jin, Wei Xu,Kai Zhao*.Curcumin encapsulation in self-assembled nanoparticles based on amphiphilic palmiticacid-grafted-quaternized chitosan with enhanced cytotoxic, antimicrobial and antioxidant properties.International Journal of Biological Macromolecules.2022, 222: 2855-2867.(SCI IF8.2)
出版著作及教材:
(1)趙凱、曹宏偉著.新城疫納米緩釋疫苗的研制及其免疫效果.科學普及出版社,ISBN 978-7-110-08370-5,2014.8
(2)趙凱著.紫杉醇高產菌株的選育及其生物合成的調控.中國科學技術出版社,26.6萬字,ISBN 978-7-5046-5165-5,2009.1
(3)趙凱參編著.動物基因工程疫苗原理與方法.化學工業出版社,ISBN 978-7-122-04824-0,2009.5
科研獲獎:
(1)趙凱(1).新城疫疫苗生物降解微膠囊緩釋劑和耐熱凍干保護劑的研制及應用,黑龍江省人民政府,黑龍江省科學技術獎(技術發明),一等獎,2014.8
(2)趙凱(1).可降解生物材料合成及其在獸用疫苗中的應用,黑龍江省人民政府,黑龍江省科學技術獎(自然科學),二等獎,2013.11
主持科研項目(部分):
(1)國家自然科學基金面上項目,《mRNA疫苗遞送系統的構建及其增強豬腸道粘膜免疫應答作用機制的研究》(32370987),2024.1-2027.12,50萬元,主持。
(2)國家自然科學基金面上項目,《殼聚糖季銨鹽水凝膠激活I3K和ERK1/2通路調控VEGF分泌促進血管新生的分子機制解析》(32170844),2022.1-2025.12,58萬元,主持。
(3)國家自然科學基金面上項目,《N-2-羥丙基三甲基氯化銨殼聚糖-N, O-羧甲基殼聚糖為佐劑制備H9N2禽流感病毒基因納米疫苗經黏膜遞送的效果及機制》(31771000),2018.01-2021.12,72萬元,主持。
(4)國家自然科學基金面上項目,《N-2-羥丙基二甲基乙基氯化銨殼聚糖/N,O-羧甲基殼聚糖納米粒新城疫疫苗的制備及免疫作用機制研究》(31570929),2016.01-2019.12,72萬元,主持。
(5)國家自然科學基金面上項目,《新城疫DNA疫苗三甲基殼聚糖納米粒黏膜免疫傳遞系統的構建及其免疫作用機制研究》(31072119),2011.1-2013.12,33萬元,主持。
(6)國家重點研發計劃,《以LDH@SiO2為遞送載體研發新城疫緩釋納米疫苗》(2017YFD0500706),2017.07-2020.12,55萬元,主持。
(7)國家重點研發計劃項目,《以改性多糖為佐劑制備豬流行性腹瀉緩釋納米疫苗》(2017YFD0500603),2017.07-2020.12,58萬元,主持。
(8)國家科技部國際科技合作專項,《豬支原體肺炎滅活疫苗技術合作開發》(2012DFA30250),2012.5-2015.12,30萬元,主持。
(9)教育部科學技術研究重點項目,《新城疫N-2-羥丙基三甲基氯化銨殼聚糖納米粒DNA疫苗制備及免疫作用機制研究》(212048),2012.1-2014.12,10萬元,主持。
(10)浙江省科技計劃項目-重點研發計劃項目,《安全高效生物獸藥研發—防控豬重要病毒性疫病的安全高效獸藥檢測新試劑研發》(2022C02031),2022.1至2024.12,1200萬元,主持。